With the increasing importance of bioinformatics in agriculture, molecular medicine, microbial genome applications, etc. the research in this field has gained momentum than ever before. Bioinformatics, also known as computational biology, deals with interpreting biological data by using computer science and information technology. Of lately, research in bioinformatics has produced vast amounts of data and will continue to generate proteomic, genomic, etc. data. To analyze and gain deep insights into such biological data necessitates making sense of the information by inferring the data. For instance, gene classification, protein structure prediction, clustering of gene expression data, protein-protein interactions, etc. These processes, in turn, increases the need for interaction between bioinformatics and data mining. Data mining, also regarded as Knowledge Discovery in Database (KDD) is the automated extraction of patterns that represent the knowledge stored or captured in large sets of data. Some of the steps included in the KDD process are data collection, selection, transformation, visualization, and assessment of extracted knowledge. The processes involved in mining precise and meaningful data pattern are: Classification – This involves learning of a function that classifies input data items into predefined classes. Estimation – It shows value for unknown variables with a given data input value. Prediction – Although the prediction involves classification and estimation, data will be classified based on the future estimated value. Association rules – Also called as dependency modeling, association rule identifies data associated and the possible outcomes. Clustering – This involves segmenting the population into clusters or subgroups. In bioinformatics, data mining leverages genetic algorithms and statistical techniques from machine learning, statistics, databases, artificial intelligence, etc. Additionally, generally mining systems including SPSS, SAS enterprise miner, S-plus, Microsoft SQL server 2000, SGI MineSet, IBM intelligent miner, etc. can be utilized for mining biological data. So, what is the need for data mining in bioinformatics? Biologists, after performing rigorous studies on...